Atp5f1a^Mom2
Spontaneous Allele Detail

Summary

• Symbol: Atp5f1a^Mom2
• Name: ATP synthase F1 subunit alpha; Modifier of Min 2
• MGI ID: MGI:3530914
• Synonyms: Atp5a1^{Mom2-C57BL/6J}, Mom2^R
• Gene: Atp5f1a Location: Chr18:77861468-77870569 bp, + strand Genetic Position: Chr18, 52.38 cM
• Alliance: Atp5f1a^Mom2 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: Spontaneous mutation arising on the C57BL/6 allele cis to the Apc^Min allele confers resistance to intestinal polyp development compared to DBA/2J. A four base-pair duplication occurs in the coding region in exon 3. This causes a frameshift leading to the predicted aberrant incorporation of 42 amino acids in the protein product and a stop codon in exon 4. Real-time PCR analysis demonstrates significantly reduced levels of Atp5a1 mRNA in intestines of heterozygous mutant mice, and sequencing of the cDNAs detects none derived from mutant transcripts. (J:73854, J:122207)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp5f1a Mutation: 38 strains or lines available

References

• Original: J:73854 Silverman KA, et al., Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia. Genome Res. 2002 Jan;12(1):88-97
• All: 4 reference(s)