Cr2^tm1Tft
Targeted Allele Detail

Summary

• Symbol: Cr2^tm1Tft
• Name: complement receptor 2; targeted mutation 1, Thomas F Tedder
• MGI ID: MGI:3531094
• Synonyms: CD21/35^-
• Gene: Cr2 Location: Chr1:194819119-194859024 bp, - strand Genetic Position: Chr1, 98.44 cM
• Alliance: Cr2^tm1Tft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95979
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' promoter region and exon encoding the transcription initiation and signal sequence of the gene were replaced by a neo cassette. Western blot analysis and binding assays failed to detect any protein or binding activity in mutant B cells and lymphocytes, respectively (J:95979)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cr2 Mutation: 84 strains or lines available

References

• Original: J:95979 Haas KM, et al., Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. Immunity. 2002 Dec;17(6):713-23
• All: 9 reference(s)