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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:35434Linkage analysis was performed on 100 female animals from a (NZW/LacJ x BALB/cJ)F1 x NZW/LacJ backcross to identify QTLs associated with autoimmune traits. 77 polymorphic markers were used in the genome scan. Linkage to autoantibody production mapped to 52 cM on mouse Chromosome 1 near D1Mit48 (P<0.001). This locus is named Baa2 (BALB/c autoimmunity 2). BALB/cJ-derived alleles at Baa2 confer increased IgM anti-ssDNA and anti-histone antibody production. Suggestive linkage to IgG anti-ssDNA antibody production mapped to 103 cM on mouse Chromosome 1 near Tgfbm2 (formerly D1Mit17). Previously identified autoimmunity QTLs mapping near this locus are Sle1 (88 cM) and Lbw7 (90 cM).Linkage to autoantibody production mapped to 27 cM on mouse Chromosome 9 near D9Mit22 (P<0.001). This locus is named Baa1 (BALB/c autoimmunity 1). BALB/cJ-derived alleles at Baa1 confer increased IgM anti-ssDNA and anti-histone antibody production. Linkage to IgG anti-ssDNA antibody production mapped to 28 cM on mouse Chromosome 11 near D11Mit207 (P=0.0031). Animals homozygous for NZW/LacJ-derived alleles at D11Mit207 are more likely to exhibit elevated serum IgG anti-ssDNA antibodies. A previously identified autoimmunity QTL mapping near this locus is Lbw8 (29 cM).1.22.2016 Curator Note: Because Lbw8 was originally mapped in 1994 in J:20991 using an (NZB/BlScr x NZW/LacScr)F2 intercross, which differs from the mapping population used here, we consider the current study a separate experiment and have named the QTL identified here Nwa3, New Zealand White autoimmunity 3. The strongest linkage to IgG anti-ssDNA antibody production mapped to the H2 locus on mouse Chromosome 17 (P=0.0004). Animals heterozygous at the H2 locus exhibit increased susceptibility to elevated IgG antibodies. Linkage to IgG anti-ssDNA antibody production mapped to 38 cM on mouse Chromosome 19 near D19Mit11 (P=0.0005). This locus is named Nwa2 (New Zealand White autoimmunity 2). Animals homozygous for NZW/LacJ-derived alleles at Nwa2 are more likely to exhibit elevated serum IgG anti-ssDNA antibodies. Nwa2 also shows weak linkage to IgG anti-histone antibodies (LOD=1.09).Suggestive linkage to IgG anti-ssDNA antibody production mapped to 32 cM on mouse Chromosome 16 near D16Mit5. Animals homozygous for NZW/LacJ-derived alleles at these loci are more likelyto exhibit elevated serum IgG anti-ssDNA antibodies. This locus is tentatively named Nwa1 (New Zealand White autoimmunity 1). Suggestive linkage to IgG anti-histone production mapped to 20 cM on mouse Chromosome 14 near the Tcra locus (P=0.0017). Animals homozygous for NZW/LacJ-derived alleles at this locus exhibit increased IgG anti-histone production. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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