Phox2a/Inppl1^tm1Ssch
Targeted Allele Detail

Summary

• Symbol: Phox2a/Inppl1^tm1Ssch
• Name: inositol polyphosphate phosphatase-like 1; targeted mutation 1, Stephane Schurmans
• MGI ID: MGI:3531322
• Synonyms: SHIP2^-
• Gene: Inppl1 Location: Chr7:101471839-101487419 bp, - strand Genetic Position: Chr7, 54.67 cM, cytoband F1
• Alliance: Phox2a/Inppl1^tm1Ssch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96443
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: 7.3 kb genomic sequence containing C-terminal of two genes, Inppl1 and Phox2a were disrupted by the integration of a single targeting construct. A neomycin selection cassette replaced sequence extending from Inppl1 (exons 19-29) and Phox2a (exon 3). (J:96443)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inppl1 Mutation: 45 strains or lines available

References

• Original: J:96443 Clement S, et al., The lipid phosphatase SHIP2 controls insulin sensitivity. (Erratum: Nature 2004 Oct 14;4131(7010):878). Nature. 2001 Jan 4;409(6816):92-7
• All: 1 reference(s)