Tg(Gcg-TAg)25Ddr
Transgene Detail

Summary

• Symbol: Tg(Gcg-TAg)25Ddr
• Name: transgene insertion 25, Daniel J Drucker
• MGI ID: MGI:3531421
• Synonyms: GLUTag line Y
• Transgene: Tg(Gcg-TAg)25Ddr Location: unknown
• Alliance: Tg(Gcg-TAg)25Ddr page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 2.1 kb fragment of the rat glucagon gene including 2.0 kb of the 5' flanking sequence and 58 bp of exon 1 was cloned upstream of the SV40 T antigen. Transgene expression was detected in the brainstem, hypothalamus, and the brain. (J:91490)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:91490 Lee YC, et al., Glucagon gene 5'-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice. J Biol Chem. 1992 May 25;267(15):10705-8
• All: 4 reference(s)