Dmd^tm1.1Khan
Targeted Allele Detail

Summary

• Symbol: Dmd^tm1.1Khan
• Name: dystrophin, muscular dystrophy; targeted mutation 1.1, Kazunori Hanaoka
• MGI ID: MGI:3531484
• Gene: Dmd Location: ChrX:81992476-84249747 bp, + strand Genetic Position: ChrX, 38.38 cM, cytoband C
• Alliance: Dmd^tm1.1Khan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96210
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was produced from Dmd^tm1Khan. The entire 2.4 Mb Dmd gene was removed by transient expression of cre recombinase in correctly targeted ES cells. RT-PCR and Western blot analyses failed to detect any expressions of full-length and short isoforms in muscle, cerebrum, and cerebellum. (J:96210)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmd Mutation: 154 strains or lines available

References

• Original: J:96210 Kudoh H, et al., A new model mouse for Duchenne muscular dystrophy produced by 2.4Mb deletion of dystrophin gene using Cre-loxP recombination system. Biochem Biophys Res Commun. 2005 Mar 11;328(2):507-16
• All: 7 reference(s)