Atf3^tm1Dron
Targeted Allele Detail

Summary

• Symbol: Atf3^tm1Dron
• Name: activating transcription factor 3; targeted mutation 1, David Ron
• MGI ID: MGI:3531501
• Synonyms: ATF3^-, Atf3 KO, ATF3-KO
• Gene: Atf3 Location: Chr1:190902493-190915530 bp, - strand Genetic Position: Chr1, 96.28 cM, cytoband H6
• Alliance: Atf3^tm1Dron page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91595
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon "B" which contains the AUG initiation codon. Absence of protein product was confirmed by Western blot analysis.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atf3^tm1Dron

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf3 Mutation: 21 strains or lines available

References

• Original: J:91595 Hartman MG, et al., Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol. 2004 Jul;24(13):5721-32
• All: 58 reference(s)