C1galt1^tm1Rpmc
Targeted Allele Detail

Summary

• Symbol: C1galt1^tm1Rpmc
• Name: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1; targeted mutation 1, Roger P McEver
• MGI ID: MGI:3531503
• Synonyms: T-syn^-
• Gene: C1galt1 Location: Chr6:7845224-7872042 bp, + strand Genetic Position: Chr6, 3.37 cM, cytoband A1
• Alliance: C1galt1^tm1Rpmc page

Fatal embryonic hemorrhage in C1galt1^tm1Rpmc/C1galt1^tm1Rpmc mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96775
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was placed in intron 2 and an additional loxP site was inserted 5' of exon 1. Transient cre expression resulted in the excision of exon 1 (containing the initiation site), exon 2 (with most of the catalytic domain), as well as the neomycin cassette. (J:96775)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C1galt1 Mutation: 26 strains or lines available

References

• Original: J:96775 Xia L, et al., Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. J Cell Biol. 2004 Feb 2;164(3):451-9
• All: 3 reference(s)