Abhd2^{Gt(pUHachi)8025Imeg}
Gene trapped Allele Detail

Summary

• Symbol: Abhd2^{Gt(pUHachi)8025Imeg}
• Name: abhydrolase domain containing 2; gene trap 8025, Institute of Molecular Embryology and Genetics
• MGI ID: MGI:3531515
• Gene: Abhd2 Location: Chr7:78923002-79015257 bp, + strand Genetic Position: Chr7, 44.96 cM, cytoband D2
• Alliance: Abhd2^{Gt(pUHachi)8025Imeg} page

Mutation origin

• Mutant Cell Line: AYU8025
• Germline Transmission: Earliest citation of germline transmission: J:96209
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The trap vector, pU-Hachi, was inserted into the fifth intron of the gene, resulting in the deletion of 634 bp of genomic sequences. Northern blot and RT-PCR shows the complete loss of the wild-type message that is replaced by the transcription of a fusion message. (J:96209)

Expression

In Mice Carrying this Mutation:

58 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abhd2 Mutation: 46 strains or lines available

References

• Original: J:96209 Miyata K, et al., Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene. Biochem Biophys Res Commun. 2005 Apr 1;329(1):296-304
• All: 2 reference(s)