Nbn^tm2Nus
Targeted Allele Detail

Summary

• Symbol: Nbn^tm2Nus
• Name: nibrin; targeted mutation 2, Andre Nussenzweig
• MGI ID: MGI:3531643
• Synonyms: Nbs1^loxP
• Gene: Nbn Location: Chr4:15957925-15992589 bp, + strand Genetic Position: Chr4, 6.66 cM, cytoband A
• Alliance: Nbn^tm2Nus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96102
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin cassette flanked by loxP sites was introduced into intron 1. A third loxP site was inserted into upstream of exon 1. (J:96102)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbn Mutation: 59 strains or lines available

References

• Original: J:96102 Reina-San-Martin B, et al., Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1590-5
• All: 5 reference(s)