Tg(Ins2-GP)34-20Olds
Transgene Detail

Summary

• Symbol: Tg(Ins2-GP)34-20Olds
• Name: transgene insertion 34-20, Michael BA Oldstone, MD
• MGI ID: MGI:3573699
• Synonyms: LCMV GP, RIP GP34-20, RIP-GP34-20, RIP GP H2^b, RIP-LCMV GP
• Transgene: Tg(Ins2-GP)34-20Olds Location: unknown
• Alliance: Tg(Ins2-GP)34-20Olds page

Transgene origin

• Strain of Origin: (C57BL/6 x BALB/Wehi)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene encodes the glycoprotein (GP) from Armstrong's clone of the lymphocytic choriomeningitis virus (LCMV) regulated by the rat insulin promoter. Upstream of the GP cDNA are 660 base pairs of regulatory elements in addition to the rat insulin promoter. Downstream of the GP c-DNA is the SV40 small T-antigen intron and late polyadenylation signal. RT-PCR analysis demonstrated that the transcript was expressed in the pancreas but not the thymus, spleen, liver, kidney, heart, muscle or lung. (J:81287)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:81287 von Herrath MG, et al., How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity. 1994 Jun;1(3):231-42
• All: 19 reference(s)