Clcn1^adr-mto5J
Spontaneous Allele Detail

Summary

• Symbol: Clcn1^adr-mto5J
• Name: chloride channel, voltage-sensitive 1; myotonia 5 Jackson
• MGI ID: MGI:3573744
• Gene: Clcn1 Location: Chr6:42263619-42292690 bp, + strand Genetic Position: Chr6, 20.57 cM
• Alliance: Clcn1^adr-mto5J page

Mutation origin

• Strain of Origin: B6;129S-Fcgr2b^tm1Ttk

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This mutation occurred spontaneously in a colony at The Jackson Laboratory in October, 1999. It was shown to be a remutation at Clcn1 by its failure to complement Clcn1^adr-mto2J in a complementation test.
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clcn1 Mutation: 71 strains or lines available

Notes

Mice homozygous for Clcn1^adr-mto5J are affected by a neuromuscular disorder that manifests by weaning as an apparent weakness or stiffness in the rear legs, which is particularly noticeable when the mice are picked up and put down again (as when being transferred to a new cage). The phenotype may disappear as the mice get older. Both male and female homozygotes have normal lifespans and are fertile.

References

• Original: J:94340 The Jackson Laboratory Office of Genetic Resources, Registry of Remutation at The Jackson Laboratory. MGI Direct Data Submission. 2000-2010
• All: 1 reference(s)