Aire^tm1Mmat
Targeted Allele Detail

Summary

• Symbol: Aire^tm1Mmat
• Name: autoimmune regulator; targeted mutation 1, Mitsuru Matsumoto
• MGI ID: MGI:3573749
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^tm1Mmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96580
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Neo replaced exons 5-12, including the sequences encoding the SAND, PHD1 and PHD2 regions. (J:96580)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 52 strains or lines available

References

• Original: J:96580 Kuroda N, et al., Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol. 2005 Feb 15;174(4):1862-70
• All: 10 reference(s)