Tg(Il1rn)1Dih
Transgene Detail

Summary

• Symbol: Tg(Il1rn)1Dih
• Name: transgene insertion 1, David Hirsh
• MGI ID: MGI:3573755
• Synonyms: IL-1ra^tg, IL1ra Tg
• Transgene: Tg(Il1rn)1Dih Location: unknown
• Alliance: Tg(Il1rn)1Dih page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Il1rn)1Dih expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il1rn (MGI:96547)

• Mutation details: This transgene contains the sequence encoding the secreted gene protein and approximately 2.0kb of upstream and 2.5kb of downstream untranslated flanking regions, and a site directed mutation (G to A) in exon 3. Northern blot analysis of liver tissue following LPS challenge detects overexpression. Two lines were created and called T14 and T16. (J:36387)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:36387 Hirsch E, et al., Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11008-13
• All: 5 reference(s)