Pax3^tm1(cre)Joe
Targeted Allele Detail

Summary

• Symbol: Pax3^tm1(cre)Joe
• Name: paired box 3; targeted mutation 1, Jonathan A Epstein
• MGI ID: MGI:3573783
• Synonyms: Pax3-Cre, Pax3^Cre, Pax3Cre-KI
• Gene: Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
• Alliance: Pax3^tm1(cre)Joe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96431
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pax3^tm1(cre)Joe expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax3 (MGI:97487)

• Mutation details: A targeting vector was desinged to insert the cre recombinase cDNA followed by a stop codon and a polyA signal in place of exon 1 of the endogenous locus. (J:96431, J:98272)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax3 (mouse) Summary of all recombinase alleles driven by Pax3. Comparative matrix view of recombinase activities Alliance mouse Pax3 gene page

Disease models

Expression

In Mice Carrying this Mutation:	120 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax3 Mutation: 50 strains or lines available

References

• Original: J:96431 Lang D, et al., Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature. 2005 Feb 24;433(7028):884-7
• All: 131 reference(s)