Efnb2^tm5Kln
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm5Kln
• Name: ephrin B2; targeted mutation 5, Rudiger Klein
• MGI ID: MGI:3573785
• Synonyms: ephrinB2^deltaV
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm5Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95885
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A cDNA coding for a protein lacking the C terminal valine within the PDZ domain follwed by a floxed neo casstee was inserted after exon 1. Western blot demonstrated that protein was efficiently expressed at wild-type levels. (J:95885)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 29 strains or lines available

References

• Original: J:95885 Makinen T, et al., PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev. 2005 Feb 1;19(3):397-410
• All: 1 reference(s)