Dnaja1^tm1Kate
Targeted Allele Detail

Summary

• Symbol: Dnaja1^tm1Kate
• Name: DnaJ heat shock protein family (Hsp40) member A1; targeted mutation 1, Kazutoyo Terada
• MGI ID: MGI:3573790
• Synonyms: DjA1^-
• Gene: Dnaja1 Location: Chr4:40722468-40734965 bp, + strand Genetic Position: Chr4, 20.46 cM
• Alliance: Dnaja1^tm1Kate page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96238
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neo resulted in the deletion of most of the sequences encoding the J domain and the G/F-rich domain in exons 2 and 3. Northern and Western blots of mutant testis confirmed absence of transcript and protein, respectively. (J:96238)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnaja1 Mutation: 21 strains or lines available

References

• Original: J:96238 Terada K, et al., A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis. EMBO J. 2005 Feb 9;24(3):611-22
• All: 2 reference(s)