Elf5^tm1Mapr
Targeted Allele Detail

Summary

• Symbol: Elf5^tm1Mapr
• Name: E74-like factor 5; targeted mutation 1, Melanie A Pritchard
• MGI ID: MGI:3573855
• Synonyms: Elf5^-
• Gene: Elf5 Location: Chr2:103242443-103281334 bp, + strand Genetic Position: Chr2, 54.43 cM, cytoband E3
• Alliance: Elf5^tm1Mapr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96237
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 was replaced with an NLS-LacZ-neo cassette. The construct was designed such that a fusion product containing the first 28 amino acids would be fused to Beta-gal. Northern blot of mutant mammary glands indicated that the null allele did not create any alternatively spliced transcripts. (J:96237)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elf5 Mutation: 19 strains or lines available

References

• Original: J:96237 Zhou J, et al., Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J. 2005 Feb 9;24(3):635-44
• All: 1 reference(s)