Birc6^tm1Nai
Targeted Allele Detail

Summary

• Symbol: Birc6^tm1Nai
• Name: baculoviral IAP repeat-containing 6; targeted mutation 1, Mikihiko Naito
• MGI ID: MGI:3573859
• Synonyms: Bruce^-
• Gene: Birc6 Location: Chr17:74835290-75010351 bp, + strand Genetic Position: Chr17, 45.64 cM, cytoband E3
• Alliance: Birc6^tm1Nai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96768
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An nlacZ and floxed neo was inserted in frame to replacee part of exon 2. Mice were crossed with cre-transgenic female mice to remove the floxed neo. Protein was not expressed in mutant embryos. (J:96768)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Birc6 Mutation: 240 strains or lines available

References

• Original: J:96768 Hao Y, et al., Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol. 2004 Sep;6(9):849-60
• All: 1 reference(s)