Tg(CTSG-PML/RARA)6179Ppp
Transgene Detail

Summary

• Symbol: Tg(CTSG-PML/RARA)6179Ppp
• Name: transgene insertion 6179, Pier Paolo Pandolfi
• MGI ID: MGI:3573865
• Transgene: Tg(CTSG-PML/RARA)6179Ppp Location: unknown
• Alliance: Tg(CTSG-PML/RARA)6179Ppp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CTSG-PML/RARA)6179Ppp expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PML (5371)

  Pml	(MGI:104662)

  Transgene codes for a fusion protein of PML and RARA.

  human

  RARA (5914)

  Rara	(MGI:97856)

  Transgene codes for a fusion protein of PML and RARA.

• Mutation details: The transgene expresses a fusion protein: the N-terminal 530 amino acids of PML fused to the C-terminal 402 amino acids of RARA. Transgene expression is driven by the human cathepsin G (CTSG) promoter. (J:40373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This transgene record is a representative of one of two founder lines (No. 6179 and 6380). The test population in the original study was composed of offspring from both founders.

References

• Original: J:40373 He LZ, et al., Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5302-7
• All: 3 reference(s)