Pitx3^tm1Mli
Targeted Allele Detail

Summary

• Symbol: Pitx3^tm1Mli
• Name: paired-like homeodomain transcription factor 3; targeted mutation 1, Meng Li
• MGI ID: MGI:3573869
• Synonyms: Pitx3^GFP
• Gene: Pitx3 Location: Chr19:46124124-46136765 bp, - strand Genetic Position: Chr19, 38.75 cM
• Alliance: Pitx3^tm1Mli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96772
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a splice acceptor-eGFP-ires-pac-pA cassette and a floxed PGK-hygro cassette was used to replace exons 2, 3 and half of 4. Expression of a Cre plasmid excised the floxed hygro. (J:96772)

Expression

In Mice Carrying this Mutation:	46 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitx3 Mutation: 22 strains or lines available

References

• Original: J:96772 Zhao S, et al., Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons. Eur J Neurosci. 2004 Mar;19(5):1133-40
• All: 32 reference(s)