Cdh17^tm1Ohn
Targeted Allele Detail

Summary

• Symbol: Cdh17^tm1Ohn
• Name: cadherin 17; targeted mutation 1, Kazuo Ohnishi
• MGI ID: MGI:3573870
• Synonyms: BILL-cadherin^-
• Gene: Cdh17 Location: Chr4:11758157-11817905 bp, + strand Genetic Position: Chr4, 5.35 cM, cytoband A2
• Alliance: Cdh17^tm1Ohn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96738
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 16-18, which encode the transmembrane and cytoplasmic domain, were replaced with a neomycin resistance cassette. Surface labeling and subsequent immunoprecipitation demonstrated the complete absence of protein on surface of B lineage cells. (J:96738)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh17 Mutation: 45 strains or lines available

References

• Original: J:96738 Ohnishi K, et al., Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the development of B cells at two stages. Eur J Immunol. 2005 Mar;35(3):957-63
• All: 2 reference(s)