Summary |
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Variant origin |
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Variant description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
This allele shows linkage to total serum IgM, total serum IgG, and glomerulonephritis.
Mapping and Phenotype information for this QTL, its variants and associated markersJ:88464(NZW x BALB/c.H2z)F1 x NZB and (NZB x BALB/c)F2 crosses were used to find loci linked to autoantibody production and glomerulonephritis related to lupus-like autoimmune syndrome. Whereas New Zealand Black (NZB) and New Zealand White (NZW) mice are susceptible to a lupus-like autoimmune syndrome. Serological and histological SLE traits showed linkage to regions on mouse Chromosome 12 (Sle14) at D12Mit291 with a LOD greater then 3.6. A region on Mouse chromosome 4 (Nbwa2) at D4Mit41 was linked to total serum IgM (p = 9.6 x 10-3) and IgG (p = 1.1 x 10-3) in the B-F2 cohort at 9.3 and 15.6 cM from the centromere, respectively. Various other novel QTLs were found in mouse Chromosomes 6, 7, 8, 9, and 16. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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