Rap1b^tm1Gwht
Targeted Allele Detail

Summary

• Symbol: Rap1b^tm1Gwht
• Name: RAS related protein 1b; targeted mutation 1, Gilbert C White
• MGI ID: MGI:3573929
• Synonyms: Rap1b^tm1Cw
• Gene: Rap1b Location: Chr10:117650502-117681879 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband D2
• Alliance: Rap1b^tm1Gwht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96758
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced all of the coding exons (exons 1-6). Western blot confirmed absence of protein in platelets and other tissues of mutant mice. (J:96758)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rap1b Mutation: 32 strains or lines available

References

• Original: J:96758 Chrzanowska-Wodnicka M, et al., Rap1b is required for normal platelet function and hemostasis in mice. (Correction 115: 2296). J Clin Invest. 2005 Mar;115(3):680-7
• All: 13 reference(s)