Zfp384^tm1Tnk
Targeted Allele Detail

Summary

• Symbol: Zfp384^tm1Tnk
• Name: zinc finger protein 384; targeted mutation 1, Tetsuya Nakamoto
• MGI ID: MGI:3573930
• Synonyms: CIZ^-
• Gene: Zfp384 Location: Chr6:124986108-125014833 bp, + strand Genetic Position: Chr6, 59.17 cM, cytoband F1
• Alliance: Zfp384^tm1Tnk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96747
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A lacZ-neo was inserted into exon 2, which is utilized by all alternatively spliced forms of the protein. Western blot of MEF immunoprecipitates and immunofluorescence antibody staining both confirmed the absence of protein. (J:96747)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp384 Mutation: 37 strains or lines available

References

• Original: J:96747 Nakamoto T, et al., Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice. Genes Cells. 2004 Jun;9(6):575-89
• All: 4 reference(s)