Tg(Tyr-cre)1Lru
Transgene Detail

Summary

• Symbol: Tg(Tyr-cre)1Lru
• Name: transgene insertion 1, Lionel Larue
• MGI ID: MGI:3573939
• Synonyms: Tyr::Cre, Tyr-CreA, Tyr::CreA
• Transgene: Tg(Tyr-cre)1Lru Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(Tyr-cre)1Lru page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tyr-cre)1Lru expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tyr (MGI:98880)

• Mutation details: A mouse tyrosinase promoter drives the expression of Cre recombinase. By crossing to a reporter strain, Cre activity was detected in skin melanoblasts from E11.5 and in skin, eyes, brain and peripheral nerves. (J:84391)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tyr (mouse) Summary of all recombinase alleles driven by Tyr. Comparative matrix view of recombinase activities Alliance mouse Tyr gene page

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru/0	B6.Cg-Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/0	B6.Cg-Ctnnb1^tm2Kem Tg(Tyr-cre)1Lru Tg(Dct-lacZ)A12Jkn
cn3  Disease Model	Pten^tm1Hwu/Pten^tm1Hwu Tg(Tyr-cre)1Lru/0	B6.Cg-Pten^tm1Hwu Tg(Tyr-cre)1Lru
cn4	Ppargc1a^tm2Brsp/Ppargc1a^tm2Brsp Ppargc1b^tm1Dpk/Ppargc1b^tm1Dpk Tg(Tyr-cre)1Lru/0	involves: 129 * 129X1/SvJ * C57BL/6
cn5	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Bmpr2^tm1.1Enl/Bmpr2^tm1.1Enl Tg(Tyr-cre)1Lru/Y	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2
cn6	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Bmpr2^tm1.1Enl/Bmpr2^tm1.1Enl Tg(Tyr-cre)1Lru/0	involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2
cn7	Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * DBA/2
cn8	Fscn1^Gt(OST124903)Lex/Fscn1^Gt(OST124903)Lex Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Tyr-cre)1Lru/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
cn9	Zeb2^tm1.1Yhi/Zeb2^tm1.1Yhi Tg(Tyr-cre)1Lru/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
cn10	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * CBA * DBA/2
cn11	Rest^tm1.1Yasu/Rest^+ Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * DBA/2
cn12	Yy1^tm2.1Yshi/Yy1^tm2.1Yshi Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * DBA/2
cn13	Rest^tm1.1Yasu/Rest^tm1.1Yasu Tg(Tyr-cre)1Lru/Y	involves: 129S4/SvJae * C57BL/6 * DBA/2
cn14	Atg7^tm1Tchi/Atg7^tm1Tchi Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2
cn15	Chek1^tm1Jmr/Chek1^+ Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * CBA * DBA/2
cn16	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * CBA * DBA/2
cn17	Nras^tm1Tyj/Nras^+ Tg(Tyr-cre)1Lru/0	involves: C57BL/6 * DBA/2
cn18	Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre)1Lru/0	involves: C57BL/6 * DBA/2
cn19	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Tyr-cre)1Lru/Y	involves: C57BL/6 * DBA/2

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9	cn10	cn11	cn12	cn13	cn14	cn15	cn16	cn17	cn18	cn19
show or hide all annotated terms Sex:
behavior/neurological																	√	√
abnormal behavior																	√	√
hyperresponsive to tactile stimuli																	√	√
tremors																	√	√
impaired coordination																	√	√
abnormal gait																	√	√
cellular		√					√	√						√		√		√
dilated mitochondrion														√
abnormal autophagy														√
abnormal melanoblast migration							√	√
decreased melanoblast proliferation		√
abnormal melanocyte proliferation														√				√
early cellular replicative senescence														√
abnormal DNA replication																√
oxidative stress														√
craniofacial																	√	√
abnormal cranium morphology																	√	√
digestive/alimentary system			√
abnormal intestine morphology			√
distended cecum			√
abnormal digestion			√
embryo		√					√	√		√					√	√
abnormal melanoblast migration							√	√
decreased melanoblast proliferation		√
abnormal melanoblast morphology		√					√	√		√					√	√
growth/size/body			√
slow postnatal weight gain			√
homeostasis/metabolism														√		√
abnormal autophagy														√
abnormal DNA replication																√
integument	√				√	√	√		√	√		√		√				√	√
abnormal coat/hair pigmentation					√							√		√
abnormal dorsoventral coat patterning												√
abnormal hair follicle melanocyte morphology							√			√		√							√
abnormal hair follicle melanin granule morphology					√							√
absent hair follicle melanin granules							√			√		√
abnormal hair follicle melanogenesis	√
reduced hair shaft melanin granule number	√				√		√		√
abnormal pinna hair pigmentation	√
abnormal tail hair pigmentation	√
absent coat pigmentation	√																		√
diluted coat color					√
mosaic coat color						√
abnormal hair follicle bulge morphology							√
abnormal skin morphology																		√
abnormal epidermal pigmentation														√
abnormal epidermal melanocyte morphology														√					√
decreased foot pigmentation														√
decreased tail pigmentation														√
decreased skin pigmentation												√
limbs/digits/tail														√
decreased tail pigmentation														√
mortality/aging			√														√	√
premature death																	√	√
postnatal lethality, complete penetrance			√
neoplasm																		√
increased melanoma incidence																		√
nervous system		√	√				√	√		√					√	√
abnormal melanoblast morphology		√					√	√		√					√	√
abnormal enteric nervous system morphology			√
abnormal enteric ganglia morphology			√
abnormal enteric neuron morphology			√
pigmentation	√		√	N	√	√	√		√	√	N	√	N	√	N		√	√	√
pigmentation phenotype				N							N		N		N
abnormal melanocyte proliferation														√				√
abnormal coat/hair pigmentation					√							√		√
abnormal dorsoventral coat patterning												√
abnormal hair follicle melanogenesis	√
abnormal pinna hair pigmentation	√
abnormal tail hair pigmentation	√
absent coat pigmentation	√																		√
diluted coat color					√
mosaic coat color						√
abnormal epidermal pigmentation														√
abnormal epidermal melanocyte morphology														√					√
abnormal leptomeninges pigmentation																		√
abnormal melanocyte morphology																		√
abnormal hair follicle melanocyte morphology							√			√		√							√
decreased melanocyte number										√		√							√
abnormal melanosome morphology							√							√
abnormal hair follicle melanin granule morphology					√							√
absent hair follicle melanin granules							√			√		√
reduced hair shaft melanin granule number	√				√		√		√
small melanosome					√
hyperpigmentation			√														√	√
hypopigmentation									√
decreased foot pigmentation														√
decreased tail pigmentation														√
decreased skin pigmentation												√
skeleton																	√	√
abnormal cranium morphology																	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn3
intestinal pseudo-obstruction IDs intestinal pseudo-obstruction       DOID:0080072 MESH:D007418 NCI:C34733 ORDO:2978 UMLS_CUI:C0021847 Close	√

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:84391 Delmas V, et al., Cre-mediated recombination in the skin melanocyte lineage. Genesis. 2003 Jun;36(2):73-80
• All: 43 reference(s)