Cd36^obl
Chemically induced Allele Detail

Summary

• Symbol: Cd36^obl
• Name: CD36 molecule; oblivious
• MGI ID: MGI:3573941
• Synonyms: Cd36^m1Btlr, obl
• Gene: Cd36 Location: Chr5:17986688-18093799 bp, - strand Genetic Position: Chr5, 8.11 cM
• Alliance: Cd36^obl page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This allele contains a T to A point mutation at position 1022 in exon 11, creating an early stop codon and removing 133 residues from the C-terminus of the polypeptide chain. Loss of these amino acids prevented formation of the second of two transmembrain domains. Western blot against antibodies for the amino terminal showed an absence of protein in whole cell extracts and supernatant. (J:96018)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd36 Mutation: 34 strains or lines available

References

• Original: J:96018 Hoebe K, et al., CD36 is a sensor of diacylglycerides. Nature. 2005 Feb 3;433(7025):523-7
• All: 9 reference(s)