Tirap^tm1Medz
Targeted Allele Detail

Summary

• Symbol: Tirap^tm1Medz
• Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; targeted mutation 1, Ruslan Medzhltov
• MGI ID: MGI:3573942
• Synonyms: Tirap^-, TIRAP^tm1MD
• Gene: Tirap Location: Chr9:35095847-35111587 bp, - strand Genetic Position: Chr9, 19.99 cM, cytoband A5.3
• Alliance: Tirap^tm1Medz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96773
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 640 bp exon encoding most of the coding sequence. RT-PCR of mutant mice confirmed absence of transcript. (J:96773)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tirap Mutation: 15 strains or lines available

References

• Original: J:96773 Horng T, et al., The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 2002 Nov 21;420(6913):329-33
• All: 23 reference(s)