Edn1^tm1.1Ywa
Targeted Allele Detail

Summary

• Symbol: Edn1^tm1.1Ywa
• Name: endothelin 1; targeted mutation 1.1, Masashi Yanagisawa
• MGI ID: MGI:3573945
• Synonyms: dlox, Edn1^tm1Hhua, ET-1^dlox
• Gene: Edn1 Location: Chr13:42454952-42461466 bp, + strand Genetic Position: Chr13, 20.82 cM
• Alliance: Edn1^tm1.1Ywa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96386
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2, and a neo-thymidine kinase selection cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. (J:96386, J:196635)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Edn1 Mutation: 26 strains or lines available

References

• Original: J:96386 Huang H, et al., Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. Clin Sci (Lond). 2002 Aug;103 Suppl 48:263S-266S
• All: 2 reference(s)