Gzmb^tm2.1Ley
Targeted Allele Detail

Summary

• Symbol: Gzmb^tm2.1Ley
• Name: granzyme B; targeted mutation 2.1, Timothy J Ley
• MGI ID: MGI:3574017
• Synonyms: GzmB^-/deltaPGK-neo
• Gene: Gzmb Location: Chr14:56496295-56499717 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband D3
• Alliance: Gzmb^tm2.1Ley page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96538
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The PGK-neo was removed from Gzmb^tm1Ley via transient expression of cre recombinase. This allele is missing a 350bp AvrII fragment starting within the 5' untranslated region (22 bp upstream from the initiation codon), extending through exon 1 and part of intron 1. (J:96538)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gzmb Mutation: 29 strains or lines available

References

• Original: J:96538 Revell PA, et al., Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. J Immunol. 2005 Feb 15;174(4):2124-31
• All: 9 reference(s)