Dclre1c^tm2Mcow
Targeted Allele Detail

Summary

• Symbol: Dclre1c^tm2Mcow
• Name: DNA cross-link repair 1C; targeted mutation 2, Morton J Cowan
• MGI ID: MGI:3574021
• Synonyms: mArt^-
• Gene: Dclre1c Location: Chr2:3425168-3465167 bp, + strand Genetic Position: Chr2, 1.93 cM
• Alliance: Dclre1c^tm2Mcow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96535
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6-11, encompassing 80% of the gene, were replaced with a neo. Western blot of lymphoid tissues demonstrated the lack of wild-type protein in mutants. (J:96535)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dclre1c Mutation: 31 strains or lines available

References

• Original: J:96535 Li L, et al., Targeted disruption of the artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation. J Immunol. 2005 Feb 15;174(4):2420-8
• All: 2 reference(s)