Sntb2^tm1Scf
Targeted Allele Detail

Summary

• Symbol: Sntb2^tm1Scf
• Name: syntrophin, basic 2; targeted mutation 1, Stanley C Froehner
• MGI ID: MGI:3574023
• Synonyms: beta2SynKO, Sntb2^tm1Maad
• Gene: Sntb2 Location: Chr8:107662372-107740864 bp, + strand Genetic Position: Chr8, 53.38 cM
• Alliance: Sntb2^tm1Scf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96569
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced exon 1, amino acids 1-173 which encode half of the first PH domain and the entire PDZ domain. Immunoblot confirmed the absence of protein in mutant muscle extracts. (J:96569)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sntb2 Mutation: 67 strains or lines available

References

• Original: J:96569 Adams ME, et al., Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms. J Neurosci. 2004 Nov 17;24(46):10302-9
• All: 7 reference(s)