Nr2f6^tm1Ge
Targeted Allele Detail

Summary

• Symbol: Nr2f6^tm1Ge
• Name: nuclear receptor subfamily 2, group F, member 6; targeted mutation 1, Gregor Eichele
• MGI ID: MGI:3574037
• Synonyms: Ear2^-
• Gene: Nr2f6 Location: Chr8:71826762-71834593 bp, - strand Genetic Position: Chr8, 34.43 cM
• Alliance: Nr2f6^tm1Ge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96328
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 1 and all of exon 2 are replaced by a lacZ-neo cassette. These exons encode the DNA-binding domain. Northern blot of mutants demonstrate a lack of transcript. (J:96328)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2f6 Mutation: 16 strains or lines available

References

• Original: J:96328 Warnecke M, et al., Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Genes Dev. 2005 Mar 1;19(5):614-25
• All: 8 reference(s)