Egr2^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Egr2^tm1Jmi
• Name: early growth response 2; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:3574072
• Synonyms: Egr2^lo
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm1Jmi page

Runted phenotype and hindbrain defect of Egr2^tm1Jmi/Egr2^tm1Jmi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96641
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• This hypomorphic allele resulted from the insertion of a PGK-neo into intron 1. (J:96641)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 33 strains or lines available

References

• Original: J:96641 Le N, et al., Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2596-601
• All: 3 reference(s)