Myb^M303V
Chemically induced Allele Detail

Summary

• Symbol: Myb^M303V
• Name: myeloblastosis oncogene; Met303Val
• MGI ID: MGI:3574289
• Synonyms: c-myb^h
• Gene: Myb Location: Chr10:21000834-21036883 bp, - strand Genetic Position: Chr10, 9.75 cM
• Alliance: Myb^M303V page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: An A to G transition produces a methionine-to-valine substitution at amino acid 303 in the transactivation (TA) domain of the gene. This results in a hypomorphic allele. (J:96507)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myb Mutation: 53 strains or lines available

References

• Original: J:96507 Sandberg ML, et al., c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell. 2005 Feb;8(2):153-66
• All: 4 reference(s)