Akt3^tm1Mbb
Targeted Allele Detail

Summary

• Symbol: Akt3^tm1Mbb
• Name: thymoma viral proto-oncogene 3; targeted mutation 1, Morris J Birnbaum
• MGI ID: MGI:3574346
• Synonyms: Ak3^-, Akt3-
• Gene: Akt3 Location: Chr1:176847639-177085769 bp, - strand Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
• Alliance: Akt3^tm1Mbb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96823
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence containing nucleotides 209-320 in exon 3 was replaced with a loxP flanked PGK-hygro-pA cassette, resulting in a frame shift in the ORF and a truncation of the resulting protein. Western blot of mutant brain tissue demonstrated that protein was undetectable. (J:96823)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Akt3^tm1Mbb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt3 Mutation: 42 strains or lines available

References

• Original: J:96823 Easton RM, et al., Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol. 2005 Mar;25(5):1869-78
• All: 28 reference(s)