Adamts1^tm1Mapr
Targeted Allele Detail

Summary

• Symbol: Adamts1^tm1Mapr
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 1; targeted mutation 1, Melanie A Pritchard
• MGI ID: MGI:3574351
• Gene: Adamts1 Location: Chr16:85590715-85600001 bp, - strand Genetic Position: Chr16, 48.2 cM, cytoband C3-C5
• Alliance: Adamts1^tm1Mapr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was deleted via cre-mediated recombination, removing the metalloproteinase domain and, if normal splicing occurred, would result in a frame shift leading to a truncated protein containing only a pre-/pro-domain only. Northern blot using a probe containing exons 4-8 indicated the absence of transcript. Immunohistochemistry further demonstrated the absence of expression in null ovaries. (J:96781)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Adamts1^tm1Mapr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adamts1 Mutation: 66 strains or lines available

References

• Original: J:96781 Mittaz L, et al., Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod. 2004 Apr;70(4):1096-105
• All: 7 reference(s)