Pou3f1^{tm1(Pou3f3)1Weg}
Targeted Allele Detail

Summary

• Symbol: Pou3f1^{tm1(Pou3f3)1Weg}
• Name: POU domain, class 3, transcription factor 1; targeted mutation 1, Michael Wegner
• MGI ID: MGI:3574356
• Synonyms: Oct-6^Brn-1
• Gene: Pou3f1 Location: Chr4:124551439-124554448 bp, + strand Genetic Position: Chr4, 57.86 cM
• Alliance: Pou3f1^{tm1(Pou3f3)1Weg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96824
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The ORF of the endogenous locus was replaced with the ORF of the rat Pou3f3 gene and a neo cassette. Cre mediated recombination removed the neo. Western blot demonstrated that at postnatal day 8, mutant mice expressed rat Pou3f3 in the myelinating sciatic nerves. (J:96824)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f1 Mutation: 14 strains or lines available

References

• Original: J:96824 Friedrich RP, et al., The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination. Mol Cell Biol. 2005 Mar;25(5):1821-9
• All: 2 reference(s)