Tnfrsf10b^tm1Wsed
Targeted Allele Detail

Summary

• Symbol: Tnfrsf10b^tm1Wsed
• Name: tumor necrosis factor receptor superfamily, member 10b; targeted mutation 1, Wafik S El-Diery
• MGI ID: MGI:3574360
• Synonyms: DR5^-
• Gene: Tnfrsf10b Location: Chr14:70004921-70021860 bp, + strand Genetic Position: Chr14, 36.1 cM
• Alliance: Tnfrsf10b^tm1Wsed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96816
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 and part of 5 were replaced with a PGK-neo cassette in the reverse orientation, causing a downstream frame shift. The deleted sequence encompassed the extracellular domain of the gene and encoded the cystein-rich repeats. RT-PCR analysis of mutants confirmed the lack of functional gene transcription in small bowel extracts. (J:96816)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tnfrsf10b^tm1Wsed

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf10b Mutation: 29 strains or lines available

References

• Original: J:96816 Finnberg N, et al., DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol. 2005 Mar;25(5):2000-13
• All: 17 reference(s)