Del(2Hoxd8,Hoxd9-Hoxd13)1Cx
Spontaneous Allele Detail

Summary

• Symbol: Del(2Hoxd8,Hoxd9-Hoxd13)1Cx
• Name: deletion, Chr 2, Cox 1; deletion, Chr 2, Gregory A Cox 1
• MGI ID: MGI:3574364
• Synonyms: Del1Cx, Irn, Ironside
• Gene: Del(2Hoxd8,Hoxd9-Hoxd13)1Cx Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Strain of Origin: NZW/LacJ

Mutation description

• Allele Type: Spontaneous
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd8,Hoxd9-Hoxd13)1Cx involves 10 genes/genome features (Hoxd13, Hoxd12, Hoxd11 ...) View all
• Mutation details: A large noncontiguous deletion of two neighboring regions (approximately 8 kb and 43 kb) left an approximately 2 kb region containing exon 1 of the Hoxd8 gene in the locus between the deleted regions. The end result is a functional deletion of Hox8d, d9, d10, d11, d12 and d13. The flanking genes, Evx2 and Hoxd4, remained intact. (J:103924)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd8,Hoxd9-Hoxd13)1Cx Mutation: 1 strain or line available

References

• Original: J:103924 Tarchini B, et al., HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside. Genes Dev. 2005 Dec 1;19(23):2862-76
• All: 2 reference(s)