Igh^deltaD
Allele Detail

Summary

• Symbol: Igh^deltaD
• Name: immunoglobulin heavy chain complex; delta D, Rudolf Jaenisch
• MGI ID: MGI:3574367
• Synonyms: LN1
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Strain of Origin: C57BL/6 x DBA/2

Mutation description

• Allele Type: Not Applicable
• Mutation: Undefined
• Mutation details: This mutation was found in mice derived by nuclear transplantation of a B-cell nucleus into enucleated oocytes from superovulated C57BL/6 X DBA/2 F1 female mice. A rearrangement in the B-cell nucleus occurred between the heavy chain J1 element and sequence immediately upstream of DFL16.1. This results in the elimination of all heavy chain D elements. (J:95981, J:97049)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:97049 Hochedlinger K, et al., Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature. 2002 Feb 28;415(6875):1035-8
• All: 4 reference(s)