Septin4^tm1Hs
Targeted Allele Detail

Summary

• Symbol: Septin4^tm1Hs
• Name: septin 4; targeted mutation 1, Hermann Steller
• MGI ID: MGI:3574368
• Synonyms: Sept4^-
• Gene: Septin4 Location: Chr11:87457515-87481365 bp, + strand Genetic Position: Chr11, 52.14 cM
• Alliance: Septin4^tm1Hs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96669
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 8 kb of sequence, almost the entire locus, was replaced with a neomycin resistance gene. Western blot confirmed the absence of isoforms H5 and M-Septin by probing cerebellum protein extracts from mutants with an antibody raised against a peptide from exon 1. (J:96669)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Septin4 Mutation: 42 strains or lines available

References

• Original: J:96669 Kissel H, et al., The Sept4 septin locus is required for sperm terminal differentiation in mice. Dev Cell. 2005 Mar;8(3):353-64
• All: 5 reference(s)