Adad1^tm1Reb
Targeted Allele Detail

Summary

• Symbol: Adad1^tm1Reb
• Name: adenosine deaminase domain containing 1; targeted mutation 1, Robert E Braun
• MGI ID: MGI:3574372
• Synonyms: Tenr^-
• Gene: Adad1 Location: Chr3:37117805-37165661 bp, + strand Genetic Position: Chr3, 18.3 cM, cytoband B
• Alliance: Adad1^tm1Reb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96477
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence containing 82 bp upstream of the transcription initiation site and ending 35 bases downstream of the translation initiation site was replaced by the promoterless lacZ and Pgk promoter-driven neo cassette. Northern blot analysis indicated decreased RNA expression in the testis. (J:96477)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adad1 Mutation: 29 strains or lines available

References

• Original: J:96477 Connolly CM, et al., Disruption of murine Tenr results in teratospermia and male infertility. Dev Biol. 2005 Feb 1;278(1):13-21
• All: 2 reference(s)