Septin4^tm1Ksh
Targeted Allele Detail

Summary

• Symbol: Septin4^tm1Ksh
• Name: septin 4; targeted mutation 1, Makoto Kinoshita
• MGI ID: MGI:3574373
• Synonyms: Sept4^-
• Gene: Septin4 Location: Chr11:87457515-87481365 bp, + strand Genetic Position: Chr11, 52.14 cM
• Alliance: Septin4^tm1Ksh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96670
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence, exons 2-10, was replaced with a neo. Absense of protein was confirmed by immunoblot of mutant testis. (J:96670)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Septin4 Mutation: 42 strains or lines available

References

• Original: J:96670 Ihara M, et al., Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell. 2005 Mar;8(3):343-52
• All: 5 reference(s)