Hey2^tm1Kkb
Targeted Allele Detail

Summary

• Symbol: Hey2^tm1Kkb
• Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Hiroki Kokubo
• MGI ID: MGI:3574394
• Synonyms: hesr2^-
• Gene: Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
• Alliance: Hey2^tm1Kkb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97120
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting construct was designed to delete the entire coding region by replacing it with a loxP neo cassette subsequently removed via cre mediated excision. (J:97120)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hey2 Mutation: 31 strains or lines available

References

• Original: J:97120 Kokubo H, et al., Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004 Sep 3;95(5):540-7
• All: 6 reference(s)