Cfl1^tm1.2Wit
Targeted Allele Detail

Summary

• Symbol: Cfl1^tm1.2Wit
• Name: cofilin 1, non-muscle; targeted mutation 1.2, Walter Witke
• MGI ID: MGI:3574399
• Synonyms: deltacof, n-cof^-
• Gene: Cfl1 Location: Chr19:5540483-5544059 bp, + strand Genetic Position: Chr19, 4.34 cM
• Alliance: Cfl1^tm1.2Wit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96452
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cfl1^tm1Wit mice were crossed to Cre-deleter mice to delete exon 2 and the neo cassette. The deletion created a frame shift and immediate translational stop. Western blot confirmed absence of protein in mutant embryo lysates. (J:96452)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfl1 Mutation: 26 strains or lines available

References

• Original: J:96452 Gurniak CB, et al., The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005 Feb 1;278(1):231-41
• All: 6 reference(s)