Tbx15^tm1Akis
Targeted Allele Detail

Summary

• Symbol: Tbx15^tm1Akis
• Name: T-box 15; targeted mutation 1, Andreas Kispert
• MGI ID: MGI:3574402
• Synonyms: Tbx15^-
• Gene: Tbx15 Location: Chr3:99147697-99261575 bp, + strand Genetic Position: Chr3, 43.03 cM
• Alliance: Tbx15^tm1Akis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96466
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ and floxed neo were introduced into exon 3, leading to a truncation of the ORF early in the T box domain, resulting in a functional null allele. A Beta-galactosidase assay demonstrated lacZ expression in mutants. (J:96466)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	30 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx15 Mutation: 46 strains or lines available

References

• Original: J:96466 Singh MK, et al., The T-box transcription factor Tbx15 is required for skeletal development. Mech Dev. 2005 Feb;122(2):131-44
• All: 2 reference(s)