Spry1^tm1.1Jdli
Targeted Allele Detail

Summary

• Symbol: Spry1^tm1.1Jdli
• Name: sprouty RTK signaling antagonist 1; targeted mutation 1.1, Jonathan D Licht
• MGI ID: MGI:3574404
• Synonyms: Spry1^-
• Gene: Spry1 Location: Chr3:37694096-37698747 bp, + strand Genetic Position: Chr3, 18.46 cM
• Alliance: Spry1^tm1.1Jdli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96485
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Spry1^tm1Jdli to cre deleter mice removed the entire coding sequence. RT-PCR of newborn kidney extracts demonstrated the absence of transcript in mutants. (J:96485)

Disease models

Expression

In Mice Carrying this Mutation:	157 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Spry1^tm1.1Jdli

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spry1 Mutation: 16 strains or lines available

References

• Original: J:96485 Basson MA, et al., Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005 Feb;8(2):229-39
• All: 33 reference(s)