Tns3^Gt(XK294)Byg
Gene trapped Allele Detail

Summary

• Symbol: Tns3^Gt(XK294)Byg
• Name: tensin 3; gene trap XK294, BayGenomics
• MGI ID: MGI:3574415
• Synonyms: Tensin3ⁱⁿ, Tns3^{Gt(Beta-geo)1Shlo}
• Gene: Tns3 Location: Chr11:8381652-8614681 bp, - strand Genetic Position: Chr11, 4.99 cM
• Alliance: Tns3^Gt(XK294)Byg page

Mutation origin

• Mutant Cell Line: XK294
• Germline Transmission: Earliest citation of germline transmission: J:96666
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A gene trap vector, pGTOLxf, was inserted into intron 4 of the gene. The vector contained the En2 splice acceptor and Beta-geo cDNA. Western blot confirmed inactivation of the gene. (J:96666)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XK294	CC248939 ; (MGI Seq Detail)	5' RACE	Chr11:8529087-8550582 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  703 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tns3 Mutation: 554 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:96666 Chiang MK, et al., Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Dev Biol. 2005 Mar 15;279(2):368-77
• All: 3 reference(s)