Sf3b1^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Sf3b1^tm1Hko
• Name: splicing factor 3b, subunit 1; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:3574428
• Synonyms: Sf3b1^-
• Gene: Sf3b1 Location: Chr1:55024328-55066640 bp, - strand Genetic Position: Chr1, 27.98 cM
• Alliance: Sf3b1^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96358
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Four exons were replaced with a neo cassette in reverse transcription orientation. Northern and Western blot confirmed a decrease in transcript and protein in heterozygous mutants. (J:96358)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sf3b1 Mutation: 74 strains or lines available

References

• Original: J:96358 Isono K, et al., Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 2005 Mar 1;19(5):536-41
• All: 6 reference(s)